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Balancing Estrogen and Progesterone

Hormonal health is all about balance – but achieving the right balance can be a challenge, particularly for women at midlife. One of the most striking examples of this dynamic is found in women whose estrogen and progesterone balance is off kilter. The wide range of resulting symptoms can be debilitating, and women can find themselves battling heavy periods, disruptive PMS, fatigue, and many more symptoms.

How can balance be restored for optimum well-being? Let’s take a look at how hormones influence your health and how a healthy lifestyle can help. 

Hormones’ Role In Your Health

Your body contains over 50 different types of hormones, and they all act as chemical messengers to other parts of the body. Hormones are secreted by endocrine glands, including the:

  • Pituitary gland
  • Pineal gland
  • Thymus
  • Thyroid
  • Adrenal glands
  • Pancreas
  • Testes
  • Ovaries

When hormones are released by endocrine glands, they travel to specific receptor sites, where they “lock in” and transmit a message to perform a specific action.

What does this mean in practical terms? Your hormones control almost every function in your body, including:

  • Maturity and growth
  • Metabolism of food items
  • Hunger
  • Sleep
  • Sexual function and reproductive health
  • Mood
  • Cognitive ability
  • Stress response
  • Appetite

Hormones also work in tandem with each other. A good example is the relationship between progesterone and estrogen, two hormones produced by the ovaries that work together to regulate the menstrual cycle.

Estrogen and progesterone have complementary functions. Estrogen is the more energizing of the two and helps with memory, libido, mood, sleep and many other functions. It helps protect bone density, youthful skin and hair, mental sharpness, and healthy cholesterol levels. Estrogen levels rise in the follicular phase, which is the first half of the menstrual cycle, up to the point of ovulation. 

Progesterone is produced after ovulation occurs (the period called the luteal phase) and has a more calming function. Progesterone levels peak about midway through the luteal phase, then drop off before menstruation occurs. This sudden drop can contribute to symptoms of premenstrual syndrome (PMS). Progesterone helps regulate the effects of estrogen on the body. It plays a role in the growth of the uterine lining during menstruation, and helps regulate the timing of menstruation.

As you see, both hormones play vital functions in a woman’s body, but they must be balanced. Having inadequate levels of progesterone is not only problematic on its own, but estrogen doesn’t function as well with low levels of progesterone. When your levels of estrogen and progesterone aren’t balanced, estrogen dominance can occur.

Estrogen Dominance: When Hormones Go Off Kilter

Without the balancing influence of progesterone, estrogen’s influence on the body can lead to troubling symptoms. Women who previously hadn’t experienced trouble with their periods may find themselves bleeding far heavier than before. They may struggle with PMS or wonder where their wild mood swings came from. The symptoms of estrogen dominance include:

  • Heavy periods
  • Menstrual cramps
  • Fertility issues
  • Blood sugar problems
  • Weight gain, particularly around the belly
  • Thyroid problems
  • Higher risk of developing autoimmune diseases
  • Bloating
  • Fatigue
  • PMS
  • Mood disorders, including anxiety and depression
  • Anger management issues
  • Increased risk of breast, uterine, and ovarian cancers

What Causes Estrogen Dominance?

Many factors can lead to estrogen imbalance, and it’s not uncommon for a woman to experience more than one cause.

  • Problems in other parts of the body can contribute to estrogen dominance, including poor liver function, since the liver helps eliminate excess estrogen.
  • Other hormones also influence estrogen and progesterone production, particularly insulin and cortisol, so when those hormones are disrupted, the effects can cascade.
  • Chronic stress can lead to harmful hormonal fluctuations.
  • A poor diet can also lead to hormonal problems, because magnesium, zinc, protein, and B vitamins help to metabolize estrogen. In addition, since fat cells produce estrogen, obesity can contribute to excess levels.
  • Normal age-related fluctuations in hormone levels can create imbalances, particularly during the perimenopause years. Women experiencing polycystic ovary syndrome (PCOS) are also vulnerable.
  • Interestingly, sometimes estrogen dominance isn’t caused by estrogen itself. Xenohormones are compounds that mimic the properties of estrogens. They can be absorbed by the body and trigger estrogen production, leading to further imbalances. Many common products contain xenohormones, including plastics (watch out for plastic food containers in particular), pesticides, factory-farmed meat, car exhaust, and emulsifiers found in shampoo and other beauty products.

How To Balance Estrogen and Progesterone

1 – Reduce stress.

Stress, particularly the chronic stress so common in our modern lives, impacts cortisol production, which in turn impacts other hormones, including progesterone. Stress reduction techniques such as meditation and yoga can help regulate stress and hormone levels. Sometimes, a simple attitude shift in attitude can slow the “flight or fight” response that produces cortisol. To do this, try considering a stressful event in a more positive light – perhaps as an opportunity to prove your strength.

2 – Get enough sleep.

Hormonal imbalances can cause sleep disturbances. At the same time, you need adequate sleep to maintain healthy hormonal balance. If this seems frustrating, it is! Work with a healthcare practitioner to address stubborn sleep issues and avoid sleep medications.

3 – Maintain a healthy liver and gut.

Your liver metabolizes estrogen, so it’s imperative to maintain optimum liver health by reducing exposure to toxins and minimizing alcohol. In addition, your gut microbiome also plays a role in estrogen regulation. Probiotic supplements, fermented foods like kimchi and sauerkraut, and drinks like kefir help maintain the “good” bacteria in the microbiome. Fiber consumption triggers the production of more bacteria, so increase your fiber intake with a focus on whole grains and produce. High amounts of fiber can also lead to more bowel movements, which helps eliminate excess estrogen.

4 – Eat for hormone health.

The traditional Western diet of highly processed, high-sugar foods is linked to higher estrogen production. In contrast, a Mediterranean diet has been shown to reduce estrogen levels. The Mediterranean diet centers around whole grains, brightly colored vegetables, olive oil, and fish. Green, leafy vegetables like kale and spinach are particularly beneficial.

Protein is essential for the production of amino acids, which are the building blocks of hormones. Some evidence shows that vegetarian sources of protein are the most effective in regulating estrogen – but the most important factor is to avoid meat from animals exposed to pesticides and artificial hormones.

Omega-3 fatty acids help regular insulin and cortisol production and reduce inflammation, which has a beneficial effect on estrogen. Foods high in omega-3 include chia seeds, avocados, many nuts, and fatty fish.

5 – Improve hormone receptivity with exercise.

Some research shows that regular exercise can make your body more receptive to the messages carried by hormones. Plus, exercise can help reduce excess body fat, which carries estrogen.

6 – Consider replacement.

The decision to start hormone therapy can be complex, with many factors to consider, including a woman’s age and overall health. It’s important to work with a healthcare practitioner to find a solution that works for you.

In bioidentical hormones, the hormones are derived from plants and are identical to the hormones produced in your body. These can be customized based on your unique hormone profile. Traditional hormone replacement therapy (HRT) is synthetic. The hormones are close to those in your body, but not always exactly the same. Long-term use of HRT carries many risks, including increased rates of certain cancers, heart disease, and strokes.

If you recognize any symptoms of hormonal imbalance, we can help! Reach out to get a comprehensive assessment of your hormones and a customized plan for rebalance. You don’t have to live with an imbalance of hormones!

Sources:

Paterni I, Granchi C, Minutolo F. Risks and benefits related to alimentary exposure to xenoestrogens. Crit Rev Food Sci Nutr. 2017;57(16):3384-3404. doi:10.1080/10408398.2015.1126547

Layman DK, Anthony TG, Rasmussen BB, et al. Defining meal requirements for protein to optimize metabolic roles of amino acids. Am J Clin Nutr. 2015;101(6):1330S-1338S. doi:10.3945/ajcn.114.084053

Sánchez-Zamorano LM, Flores-Luna L, Angeles-Llerenas A, Ortega-Olvera C, Lazcano-Ponce E, Romieu I, Mainero-Ratchelous F, Torres-Mejía G. The Western dietary pattern is associated with increased serum concentrations of free estradiol in postmenopausal women: implications for breast cancer prevention. Nutr Res. 2016 Aug;36(8):845-54. doi: 10.1016/j.nutres.2016.04.008. Epub 2016 Apr 26. PMID: 27440539.

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Sánchez-Zamorano LM, Flores-Luna L, Angeles-Llerenas A, Ortega-Olvera C, Lazcano-Ponce E, Romieu I, Mainero-Ratchelous F, Torres-Mejía G. The Western dietary pattern is associated with increased serum concentrations of free estradiol in postmenopausal women: implications for breast cancer prevention. Nutr Res. 2016 Aug;36(8):845-54. doi: 10.1016/j.nutres.2016.04.008. Epub 2016 Apr 26. PMID: 27440539.

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Cortisol – Effects on Women’s Health

Balance is the key element when it comes to cortisol, a hormone produced in your adrenal glands. Cortisol performs many vital functions, including:

  • Reducing inflammation
  • Regulating blood pressure
  • Metabolizing glucose
  • Assisting with circadian rhythm regulation
  • Formulating memories

Many of these tasks contribute to cortisol’s role in controlling the “flight or fight response.”  When your body senses danger, cortisol kicks in with the physiological responses that enable you to either flee the danger or fight it. Your heartbeat increases, blood flows to your major muscle groups, your nervous system is on hyper alert – all thanks to cortisol and other hormones like adrenaline. In this state of emergency preparedness, even the clotting ability of your blood increases, in case of injury. To create a fast supply of energy, you metabolize carbohydrates faster.

From an evolutionary perspective, these responses made a lot of sense. Long ago, stressors were often direct threats requiring a fast physical response, one that still serves us well in certain stressful situations.

Now, however, much of the stress in modern life is chronic stress, and we have much more sedentary lives. The cortisol our bodies release in times of stress isn’t necessarily required to initiate a physical response.

How High Cortisol Levels Affect Women

As a result of our more sedentary and stressful lives, many women suffer from an imbalance in their cortisol levels. An excess of cortisol in the body can lead to many troublesome symptoms, including:

  • Hypertension
  • Irritability
  • Weight gain, particularly in the belly and upper back
  • Unexplained fatigue
  • Difficulty focusing
  • Muscle weakness
  • Trouble concentrating
  • Headaches
  • Memory problems
  • Indigestion
  • Insomnia
  • Low libido

For menopausal women, these symptoms can be particularly pronounced. Cortisol levels rise at the end of menstruation, exacerbating menopausal symptoms at what is already a difficult time achieving hormonal balance. This is one of the main contributors to a frequent complaint among menopausal women: excess belly fat.

In menstruating women, excess cortisol can lead to painful, heavy, or absent periods. When estrogen is lowered from continuous stress and cortisol production, all the female hormone imbalance symptoms such as night sweats, sleep problems, and mood swings can get worse.

3 Key Steps to Balance Cortisol Levels

1 – Eat for success

A healthy diet is one of the most effective ways to regulate cortisol levels. Start by implementing these habits into your daily meals.

  • Reduce sugar and simple carbs. Studies show that a diet high in refined carbohydrates and sugar raises cortisol levels. Somewhat paradoxically, a high-sugar diet can also make your body less efficient producing cortisol when in a stressful situation.
  • Drink lots of water. When you’re dehydrated, your cortisol levels rise.
  • Focus on fiber. The gut microbiome influences hormone production. A healthy microbiome requires high fiber intake, in order to stimulate the production of “good’ bacteria in the microbiome,
  • Choose omega-3. The anti-inflammatory qualities in omega-3 fatty acids help reduce cortisol levels. Foods high in omega-3 include fatty fish like salmon, flax and chia seeds, and nuts like walnuts.
  • Fermented foods for gut health. Fermented foods like yogurt, kimchi, and sauerkraut help contribute to healthy bacteria levels in your gut, which helps regulate hormone production.  

2.  Supplement smartly

Supplements that reduce inflammation and improve gut health can support lower cortisol levels. Some to consider include:

  • Fish oil. Boost your consumption of omega-3 fatty acids with high quality fish oil supplements.
  • Ashwagandha. Adaptogens like ashwagandha help your body cope with stress by lowering cortisol production.
  • Chamomile. Tea made with chamomile has been a relaxation treatment for centuries, and new studies suggest it may reduce cortisol levels.

Taking any new supplementation should be discussed with a healthcare practitioner to make sure it’s the right fit for you. We can help you with a personalized wellness plan tailored to your needs.

3. Reduce daily stress

Chronic stress contributes to problems with cortisol because your body is in a constant state of alert. However, reducing stress is often easier said than done. Focus on coping mechanisms to help address the way you respond to stressful situations.

  • Get enough sleep. It’s frustrating: When we’re tired, we produce more cortisol, but that cortisol also keeps us awake! This creates a seemingly endless cycle of exhaustion. Focus on creating a relaxing nighttime routine, including a regular bedtime and a restful sleep environment. Avoid alcohol, screens, large meals, and intense exercise before bed. You want to associate sleep with peace.
  • Spend time in nature. It’s a prescription that has stood the test of time. Being outside lowers your stress responses, including cortisol production. It doesn’t have to be an epic hike – just taking a walk through the neighborhood on a busy day helps.
  • Work on your relaxation responses. Meditation, yoga, and breathwork all condition your body to deal with stressful thoughts while minimizing their physical impact.
  • Be careful with the company you keep. Ever notice that some people are inherently stressful to be around? Although positive social relationships can improve our responses to stress, negative relationships create a sense of chronic stress that isn’t good for your cortisol levels. And, don’t limit your reach to human companionship – studies have found that positive interactions with pets can lower cortisol too!

If you recognize any of the signs of high cortisol levels, it’s time to take a proactive approach to managing your response to stress. Let us know if you want to learn more about controlling cortisol levels – and improving your overall health!

Sources:

Woods NF, Mitchell ES, Smith-Dijulio K. Cortisol levels during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women’s Health Study. Menopause. 2009;16(4):708-718. doi:10.1097/gme.0b013e318198d6b2

Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014;94(12):1816-1825. doi:10.2522/ptj.20130597

Soltani H, Keim NL, Laugero KD. Increasing Dietary Carbohydrate as Part of a Healthy Whole Food Diet Intervention Dampens Eight Week Changes in Salivary Cortisol and Cortisol Responsiveness. Nutrients. 2019;11(11):2563. Published 2019 Oct 24. doi:10.3390/nu11112563

Tryon MS, Stanhope KL, Epel ES, Mason AE, Brown R, Medici V, Havel PJ, Laugero KD. Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body. J Clin Endocrinol Metab. 2015 Jun;100(6):2239-47. doi: 10.1210/jc.2014-4353. Epub 2015 Apr 16. PMID: 25879513; PMCID: PMC4454811.

Tryon MS, Stanhope KL, Epel ES, Mason AE, Brown R, Medici V, Havel PJ, Laugero KD. Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body. J Clin Endocrinol Metab. 2015 Jun;100(6):2239-47. doi: 10.1210/jc.2014-4353. Epub 2015 Apr 16. PMID: 25879513; PMCID: PMC4454811.

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019;11(12):e6466. Published 2019 Dec 25. doi:10.7759/cureus.6466

Keefe JR, Guo W, Li QS, Amsterdam JD, Mao JJ. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder. J Psychiatr Res. 2018;96:189-195. doi:10.1016/j.jpsychires.2017.10.011

Zimberg IZ, Dâmaso A, Del Re M, Carneiro AM, de Sá Souza H, de Lira FS, Tufik S, de Mello MT. Short sleep duration and obesity: mechanisms and future perspectives. Cell Biochem Funct. 2012 Aug;30(6):524-9. doi: 10.1002/cbf.2832. Epub 2012 Apr 4. PMID: 22473743.

Ewert A, Chang Y. Levels of Nature and Stress Response. Behav Sci (Basel). 2018;8(5):49. Published 2018 May 17. doi:10.3390/bs8050049

Pauley PM, Floyd K, Hesse C. The stress-buffering effects of a brief dyadic interaction before an acute stressor. Health Commun. 2015;30(7):646-59. doi: 10.1080/10410236.2014.888385. Epub 2014 Aug 4. PMID: 25090099.

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Top 10 Signs of Hormonal Imbalance

Hormones affect every aspect of your wellbeing, from your appetite to your zest for life. Despite their large impact on overall health, hormonal imbalances can be frustratingly difficult to recognize. That’s partly because our hormones must maintain a delicate balance and even a slight shift can have negative repercussions.

Key Players in Hormone Balance

Think of your hormones as messengers delivering instructions to the rest of your body in order to regulate many things, including mood, appetite, stress levels, metabolism, sleep, sexual functions, blood sugar and more!

Many organs are involved in maintaining hormone balance. The hypothalamus, a small region in your brain, sends signals to your endocrine system, which controls the secretion of hormones. The endocrine system contains the adrenals, hypothalamus, ovaries, testes, parathyroid, pineal and pituitary glands.

When these glands receive a signal from the hypothalamus, they react by releasing hormones. For example, if your brain perceives a threat, your hypothalamus tells your adrenal and pituitary glands to secrete the “stress hormones” adrenaline and cortisol. This dynamic is sometimes called the HPA axis and it has far-reaching effects on your body. Those hormones tell your heart to speed up, your muscles to tense, your breathing to quicken, and your liver to release more glucose for extra energy. Those responses likely served us well way back in history, when we were more likely to be under an actual attack, because they primed our “flight or fight” response. Today, however, stress is often more chronic, and we’re not typically able to flee or fight the stressors. Instead, the long-term effects continue to take a toll.

Who Is at Risk and Why?

We all experience some hormonal imbalances over the course of a lifetime, but certain developmental stages raise the risk. Puberty is one obvious stage when hormones are sometimes wildly out of balance because the ovaries and testes receive signals to start producing more hormones like testosterone, estrogen, and growth hormone. Middle age ushers in a new era of hormonal changes. For women, the production of estrogen starts to slow with the transition to menopause. For many women, however, this isn’t a smooth decrease in hormone production, but rather, something that occurs in fits and starts, which can make symptoms harder to manage.

Men aren’t immune from midlife hormone imbalances. Around the age of 40, men’s level of androgens (“male” hormones like testosterone) starts to decline by about one percent a year.

Outside of age-related hormonal changes, other factors can lead to hormone imbalance, including stress, disordered eating, nutritional deficiencies, medication, exposure to toxins, birth control pills, and many medical conditions.

Top 10 Signs of Hormone Imbalance

1- Bad PMS

Wild mood swings. Unexplained sadness. Disabling irritability. Premenstrual syndrome, or PMS, isn’t much fun, and hormones are to blame. PMS is caused by the drop in estrogen and progesterone that occurs in the second half of the menstrual cycle. Low estrogen and progesterone levels can lead to a decrease in the production of serotonin, a neurotransmitter that plays a vital role in mood stabilization.

2 – Mood swings

Many hormones influence our moods, including norepinephrine and epinephrine, testosterone, and oxytocin, so it is not surprising that fluctuating hormones can lead to an emotional rollercoaster, for all genders.

3 – Fatigue

Hormones play an important role in energy levels, so an imbalance often leads to unexplained fatigue. A decrease in thyroid hormone in particular can lead to extreme tiredness. And decreases in another hormone, progesterone, can make it more difficult to fall asleep.

4 – Low sex drive

Lower levels of estrogen in women and testosterone in men often lead to a loss of libido.

5 – Irregular periods

Low levels of estrogen and difficulties with thyroid hormone levels can lead to periods that don’t follow a regular 28-day cycle. As women enter the perimenopause stage, this often becomes more pronounced, and the timing of their periods becomes difficult to predict.

6 – Weight fluctuations

Anyone who struggles to control their weight, despite conscientious exercise and careful calorie control, should have their hormone levels checked.The impact of hormones on weight is complex, and can involve ghrelin, cortisol, insulin, thyroid hormone, and leptin. Imbalances with just one of these can easily derail weight-control. 

7 – Food cravings

Studies (and plenty of anecdotal evidence) suggest that hormonal fluctuations, particularly those tied to the menstrual cycle, lead to cravings for sweet and high-carb foods. Stress hormones can also play a role, as they send signals to your body that it needs more energy to fight the perceived stress. The “pleasure” hormones like dopamine can also contribute, as your body seeks to repeat the temporary feelings of satisfaction from eating certain foods.

8 – Brain fog

That feeling of not being able to think clearly can be influenced by many hormones, including cortisol, insulin, estrogen and testosterone.

9 – Headaches

For women, low levels of estrogen can lead to an increase in headaches. Imbalances in other hormones, such as cortisol and thyroid hormone, can also contribute.

10 – Sleep problems

Disruptions in levels of the sleep-inducing hormone melatonin lead to issues with your circadian rhythm, but other hormones also play a role in a good night of sleep.

Restoring Balance

As you can see from the above list, hormonal imbalances can lead to many health issues. It’s important to note their connectivity: Hormones influence each other in a complex chain. For example, a disruption in melatonin levels can lead to less sleep. In turn, not getting enough sleep can inhibit testosterone production, even in young men. It’s all connected!

These intertwined relationships point to the importance of taking a holistic approach to hormonal balance. Here are just some proven strategies that we use in our practice:

Maintain a healthy body weight.

Yes, this can feel like a Catch-22 when your hormones aren’t cooperating. Focus on whole, natural foods, centered around organic produce and high-quality protein sources, healthy fats, and whole grains. Avoid drastically reducing calories, as that can be counterproductive. Eliminate, or reduce, alcohol and caffeine, and processed foods.

Practice stress reduction.

Stress reduction helps stabilize hormones by minimizing the flight or fight response and its impact on hormones. Studies point to the success of meditation and other stress-reduction activities such as yoga or tai chi.

Incorporate exercise into your life.

Even simple walking can regulate hormone levels. Work with a knowledgeable professional to figure out what’s the best approach for you. 

Minimize the use of hormone disruptors.

We’re growing increasingly aware of the impact of certain chemicals on our hormones. Some chemicals, for example, “mimic” certain hormones, which confuses the body’s response. Others change the way we process hormones, or change our sensitivity to them. These chemicals can be found in pesticides, many kinds of packaging, household cleaners, cosmetics and toiletry items, and more. It all points to the importance of becoming an informed consumer.

Investigate natural supplements.

More research needs to be done on the effectiveness of natural supplements to balance hormones, but historically, people have turned to supplements such as ginseng, black cohosh, evening primrose oil, and red clover. 

Get tested and get balanced.

Your hormones have a profound impact on your health. Maintaining balanced hormone levels is one of the most important things you can do to enjoy a healthy life. If you’d like more information on testing and a tailored health plan to gain control of your hormones, reach out to us – we can help!

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Bae, J., Park, S. & Kwon, JW. Factors associated with menstrual cycle irregularity and menopause. BMC Women’s Health 18, 36 (2018). https://doi.org/10.1186/s12905-018-0528-

Schwarz NA, Rigby BR, La Bounty P, Shelmadine B, Bowden RG. A review of weight control strategies and their effects on the regulation of hormonal balance. J Nutr Metab. 2011;2011:237932. doi:10.1155/2011/237932

Benton D, Young HA. Reducing Calorie Intake May Not Help You Lose Body Weight. Perspect Psychol Sci. 2017;12(5):703-714. doi:10.1177/1745691617690878

Sudsuang R, Chentanez V, Veluvan K. Effect of Buddhist meditation on serum cortisol and total protein levels, blood pressure, pulse rate, lung volume and reaction time. Physiol Behav. 1991 Sep;50(3):543-8. doi: 10.1016/0031-9384(91)90543-w. PMID: 1801007.

Menstrual cycle hormones, food intake, and cravingsSridevi Krishnan, Rebecca Tryon, Lucas C Welch, William F Horn, Nancy L KeimFirst published: 01 April 2016 https://doi.org/10.1096/fasebj.30.1_supplement.418.6

Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009;30(4):293-342. doi:10.1210/er.2009-0002

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study, Minoru Yamada 1, Shu Nishiguchi 2, Naoto Fukutani 2, Tomoki Aoyama 2, Hidenori Arai  DOI: 10.1016/j.jamda.2015.02.017

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Staying Balanced During Perimenopause: Five Steps for Success

The scientific explanation of perimenopause sounds so simple: a gradual slowing down of reproductive hormones until menopause.The reality, however, is that for many women the arrival of menopause isn’t a smooth, gliding descent but more of a turbulent landing complete with bumps, twists, and what can feel like the constant threat of a complete crash. That feeling is compounded by the timing, since perimenopause symptoms often begin at a particularly stressful time of life with mounting work and family demands. Add in the physical and emotional effects of hormonal fluctuations, and the entire process can easily start to feel like a cruel joke.

Thankfully it doesn’t have to be that way.

If you’re frustrated by symptoms like mood swings, weight gain, and anxiety, start by taking a deep breath. The first step to thriving not just surviving perimenopause is to acknowledge that is a natural process. Don’t beat yourself up. Now is the time to give your body – and your mind – some love.

How to Recognize Perimenopause

It is interesting to note that some studies show our attitudes towards menopause (and aging in general) can impact how we experience perimenopause symptoms.

Know What to Expect

Knowing what to expect and what triggers perimenopause is important. Sometimes, women are baffled by the changes and blame themselves, telling themselves that they’re not working out hard enough or not coping well with stress. That’s why a good understanding of the changes you’re undergoing is important.

This Phase Can Last Years

Perimenopause symptoms typically begin in the mid-forties and continue for a number of years until full menopause is reached, which is defined as having gone a full year without a menstrual period, marking the cessation of the release of eggs. Over this period, the ovaries’ hormonal production slows down in fits and starts, leading to fluctuating levels of estrogen, which creates shifting imbalances in the delicate seesaw of estrogen and progesterone. Earlier in life, estrogen levels are much more predictable with the menstrual cycle.

Signs You May Be in Perimenopause

Symptoms can be subtle at first and easily mistaken for something else. They may increase gradually, or you may find they come and go along with your fluctuating hormones, they can include:

  • Changes in menstruation, which could include changes in timing (both more frequent or less frequent) and periods that are suddenly much heavier
  • Unexplained weight gain, particularly around the midsection
  • Depression
  • Brain fog
  • Hot flashes
  • Tender breasts
  • Anxiety and panic attacks
  • Restless legs
  • Insomnia and difficulty staying asleep
  • Irritability
  • Changes in libido
  • Vaginal dryness
  • Acne (as if wrinkles weren’t enough to worry about)

5 Ways to Find Balance During Perimenopause

The good news is that several lifestyle changes can help maintain hormonal balance and make it easier to cope with the changes that do occur.

1 – Aim for a Good Night’s Sleep

Ironically, getting restful sleep can become more challenging just when we need it most, and a majority of perimenopausal women report sleep difficulties. Waking up frequently is the most common complaint, often due to hot flashes. As always, a holistic approach helps, as a hormone-supporting diet can help regulate hot flashes.

How You Can Strengthen Your Bedtime Routine

In addition, it’s important to practice good sleep hygiene:

  • Avoid using electronic devices at least one hour before bedtime.
  • Avoid caffeine, large meals, and vigorous exercise in the evening.
  • Build a predictable wind-down routine into your evenings.
  • Keep your bedroom temperature on the cooler side for better sleep.
  • Avoid synthetic materials in bedding and sleepwear in favor of natural fabrics like cotton or linen.

Since melatonin production slows with age, melatonin supplements may be necessary. A healthcare practitioner can help assess the need for supplements.

2 – Address Your Stress

The stress hormone cortisol rises with age, which is partly to blame for the increase in belly fat many women experience during perimenopause. Taking proactive steps to reduce stress will help get a handle on cortisol levels.

Find Out What Works Best for You

Adequate sleep helps to lower cortisol, as does gentle, mindful activity such as yoga or tai chi. In fact, studies have found that mindful activities can reduce hot flashes, which will favorably impact sleep, which in turn helps to reduce belly fat – it’s all connected!

3 – Get Moving

Regular exercise helps with stress, reduces body fat, and improves your overall quality of life. It’s important to acknowledge, however, that what worked in your 20s and 30s may not be as effective at this stage of life.

Consider Reducing the Intensity

Somewhat ironically, overly intense exercise can overtax your body and result in an increase in cortisol. Remember those stress tips above? That’s why it’s important to find a form of exercise that works for you. Don’t feel pressure to do high-intensity workouts if your body responds better to lower-intensity programs like Pilates or walking. Because everybody is different, it may take a bit of trial and error to find what works for you. The best exercise is always the one that you will stick to, and the one that gives you joy instead of adding to your stress levels.

4 – Eat a Hormone-Supportive Diet

The concept of being gentle with your body during perimenopause extends to your diet. At this stage in life, you should focus on foods that support hormonal balance and provide nourishment. The four pillars of a healthy perimenopause diet are:

Protein

You start to lose muscle with age, so it’s important to counteract that adequate protein to retain muscle mass. Choose lean proteins, including some plant-based sources like chickpeas and lentils.

Fiber

A slowed metabolism may also slow down digestion. This may lead to constipation and foods hanging around longer causing fermentation = gas and bloating.Fibre helps food move smoothly through the bowels and also helps us feel fuller for longer, limiting cravings. Fibre can be found in loads of foods from flaxseed, chia seed, beans and legumes to spinach, broccoli, apples and pears.

Fat

Healthy fats, like Omega-3 fatty acids, can help reduce hot flashes and may boost mood, according to some studies. Good sources of Omega-3 include salmon, hemp seeds, and flax seeds.

5 – Manage your Blood Sugar and Insulin Levels

High blood sugar can exacerbate hot flashes and other perimenopausal symptoms. This can be a bit of a vicious cycle, since changing hormonal levels can actually raise the production of the hormone insulin, which regulates blood sugar. It’s crucial to limit consumption of processed carbohydrates and sweet drinks during perimenopause, as insulin resistance becomes more commonplace. Fiber and protein can help preserve insulin sensitivity, so instead of a quick hit of something sweet for a snack, look for more satiating foods like nuts or whole grains.

A lot is happening during perimenopause for many women – career, family, decisions about the future – but taking some time to focus on your own health will help you feel empowered with the changes in your body.

If you are looking for extra support or experiencing hormonal issues and would like to dive deeper into what’s going on and the best natural course of action give us a call. As integrative doctor’s we can help guide you in this transition in a healthy and holistic way.

Sources

Fiona C Baker, Massimiliano de Zambotti,Ian M Colrain,Bei Bei. Sleep problems during the menopausal transition: prevalence, impact, and management challenges. Nat Sci Sleep. 2018 Feb 9;10:73-95. doi: 10.2147/NSS.S125807. eCollection 2018.

M Karasek. Melatonin, human aging, and age-related diseases. Exp Gerontol. Nov-Dec 2004;39(11-12):1723-9. doi: 10.1016/j.exger.2004.04.012.

James Carmody, Ph.D., Associate Professor of Medicine, Sybil Crawford, Ph.D., Professor of Medicine, Elena Salmoirago-Blotcher, M.D., Doctoral Fellow, et al. Mindfulness Training for Coping with Hot Flashes: Results of a Randomized Trial. Menopause. 2011 Jun; 18(6): 611–620. doi: 10.1097/gme.0b013e318204a05c

Nancy Fugate Woods, PhD, RN, FAAN, Ellen Sullivan Mitchell, PhD, and Kathleen Smith-DiJulio, PhD, RN. Cortisol Levels during the Menopausal Transition and Early Postmenopause: Observations from the Seattle Midlife Women’s Health Study. Menopause 2009 Jul–Aug; 16(4): 708–718. doi: 10.1097/gme.0b013e318198d6b2

The North American Menopause Society. The role of calcium in peri-and postmenopausal women: consensus opinion of The North American Menopause Society. Menopause. Summer 2001;8(2):84-95. doi: 10.1097/00042192-200103000-00003.

Diana Carter, MBBS. DEPRESSION AND EMOTIONAL ASPECTS OF THE MENOPAUSE – BCMJ, vol. 43 , No. 8 , October 2001 , Pages 463-466.

Marlene P. Freeman, MD,1 Joseph R. Hibbeln, MD,2 Michael Silver, MS et al

Marlene P. Freeman, MD,1 Joseph R. Hibbeln, MD,2 Michael Silver, MS et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. Menopause. 2011 Mar; 18(3): 279–284. doi: 10.1097/gme.0b013e3181f2ea2e

Rebecca C Thurston 1, Samar R El Khoudary et al. Vasomotor symptoms and insulin resistance in the study of women’s health across the nation. J Clin Endocrinol Metab. 2012 Oct;97(10):3487-94. doi: 10.1210/jc.2012-1410. Epub 2012 Jul 31.

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The Connection Between Gluten and Thyroid Issues

By now, you’ve likely heard about gluten intolerance. The buzz word “gluten-free” is everywhere in the health world. But how impactful is gluten? For those with thyroid issues, it may be affecting you more than you realize.

Thyroid Conditions Are Fairly Common

About 20 million Americans are currently suffering from a form of thyroid disease. And roughly 60% don’t know it. Thyroid disorders are particularly common in women with one in eight females going on to develop a thyroid condition within her lifespan, and women are five to eight times more likely to have thyroid issues than men.

Your Thyroid Can Be Under or Over Performing

A malfunctioning thyroid can lead to either over or under-production of thyroid hormones. These hormones — called T3 and T4 — affect every organ system in your body.

Your heart, central nervous system, autonomic nervous system, bone, gastro-intestinal tract and metabolism all obey the orders of our thyroid hormones.

A Holistic Approach

Whether the issue is hyperthyroidism, hypothyroidism, Grave’s disease, or Hashimoto’s thyroiditis, the symptoms of thyroid issues can vary in severity from moderate to life-changing. That’s why functional practitioners take a holistic approach to tackle thyroid issues from all angles – and that includes nutrition.

Recent research links gluten intolerance and auto-immune issues, meaning if an auto-immune condition is the underlying cause of your thyroid disorder, your relationship with gluten may be an exacerbating factor. This connection happens so often that some studies suggest gluten intolerance screening for anyone with auto-immune thyroid issues.

Auto-Immune Thyroid Issues

If you have an auto-immune thyroid issue, eliminating gluten entirely is critical to fully understanding your condition. Even eating small amounts can cause immune reactions lasting up to six months, so complete elimination is needed in order to notice any difference in your symptoms.

Gluten-free diets can be tricky to maintain, but the results are worth the trouble. Your gluten intake may be the critical factor affecting the function (or auto-destruction) of your thyroid.

How Does Gluten Lead to Autoimmunity?

When you ignore food sensitivities, your gut often pays the price in inflammation. Over time, inflammatory foods (like gluten) can degrade the delicate lining of your small intestine, leading to permeability or “leaky gut”. When this happens, food particles are able to slip past the protective mucosal layer, between the cells lining the intestinal wall, and reach your bloodstream. The protein portion of gluten — called gliadin — is a common culprit.

Mistaken Identity

The immune system targets these proteins as foreign particles and begins to attack them. Unfortunately, gliadin protein molecules are strikingly similar to the molecules that make up the thyroid gland. Once antibodies to gliadin are created, they can mistakenly attack thyroid tissue. From that point on, you have an auto-immune response to gluten.

A Gluten Intolerance Can Be Hidden

Many people misinterpret gluten intolerance as a “digestive” issue only. But it can affect far more than just the digestive system. Antibodies triggered by this kind of gluten intolerance travel throughout the whole body: the joints, skin, respiratory tract and brain can all  be affected. In fact, for some people affected, no digestive symptoms are seen at all. With a wide variety of possible symptoms, gluten sensitivity may take a lot of effort to uncover.

Other Grains Can Mimic Gluten

As if the situation wasn’t complex enough, once the antibodies for gluten have been created, they can mistakenly attack other proteins too. Certain grains, such as corn, oats, and rice, are naturally gluten-free yet their proteins are so similar to gluten that they occasionally still elicit an immune response. A functional doctor can help you identify which foods may trigger your gluten sensitivity.

Casein Sensitivity May Also be an Issue

Lactose intolerance is much more common than gluten intolerance. However, the two often overlap. In one study in Italy, roughly 25% of people with lactose intolerance also had celiac disease, a digestive condition that is linked to gluten-related autoimmunity.

This means that for many people, going gluten-free won’t be enough to get to the root of their auto-immune symptoms. If an intolerance to casein (the main protein in dairy) may be at play, patients are often advised to adopt both a dairy-free and gluten-free diet during the elimination phase, with dairy being added back separately to assess casein sensitivity.

How We Test for Gluten Intolerance

There are multiple ways to test for food sensitivities and ascertain whether gluten intolerance may be playing a part in your thyroid issues.

Testing for Antibodies in the Blood

Running a food sensitivity panel is one way to start learning what is going on. Although they are expensive to run and do not always lead to a clear path of action other than the complete avoidance of the foods in question, these blood tests can be vital guideposts in the dark for tricky cases.

IgA and IgG

Both IgA and IgG antibodies are tested. These antibodies are created in response to gluten particles in the bloodstream. IgA and IgG are delayed-response antibodies — they aren’t created immediately, making them a good indicator of a long-term sensitivity to gluten. However, a milder case of gluten sensitivity (when antibodies haven’t been created) may be missed, and false negatives can occur if a patient is currently avoiding gluten.

Creating a Benchmark

Your functional doctor may advise running a food sensitivity panel before you begin an elimination diet so that you have a benchmark to work with. While eliminating gluten and dairy are the most common requests, you may be asked to remove one or more other foods based on the results of your food sensitivity panel so that other potential problem foods don’t interfere with the success of your elimination phase.

The Gluten Challenge

Hypo-allergenic diets may be the most powerful tool a functional doctor can prescribe, but no bones about it: these diets can be very difficult and take a long time. The hidden benefit is that the diet you are on during the investigation eliminates your possible triggers, so you should start to feel better right away, even as you uncover the details of your sensitivity.

Luckily, when it comes to auto-immune conditions, removing dairy and gluten are often the main dietary requirements and there are many alternative foods available.

The Elimination Phase

For anywhere from two to six weeks, depending on your individual situation, you’ll remove all dairy and gluten from your diet. During this time, you’ll keep a close eye on your symptoms to see if they resolve or reduce dramatically. If symptoms don’t resolve, you may be asked to remove additional foods: like eggs or soy.

The Challenge Phase

Once your symptoms resolve, you’ll reintroduce each food one at a time. Let’s say dairy first. You’ll have dairy in every meal for three or four days while keeping note of any symptoms or sensitivity reactions. Then you’ll be instructed to stop eating dairy for three days.

If there are no reactions during elimination or in the final phase, a dairy sensitivity can be ruled out. At that point, you can safely add dairy back into your diet.

A Positive Result

Next, you will begin the challenge phase for gluten. Let’s say you did have a symptom response to gluten. At that point, you would be instructed to eliminate gluten from your diet for another three to six months before attempting the challenge again. After a longer break, some food sensitivities are no longer as offensive.

If – on the other hand – your symptoms did return when you reintroduced gluten, your naturopathic/integrative/functional doctor may diagnose you with gluten intolerance.

The health of your thyroid affects every cell in your body. If you suspect an autoimmune condition may be affecting how well you feel, please give us a call. As functional doctors, we have access to a wide array of investigative tools and lab tests to help you uncover what’s really going on – and come up with a tailored plan to help you feel like yourself again.

Resources:

Fatourechi V. Subclinical hypothyroidism: an update for primary care physicians. Mayo Clinic proceedings. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664572/. Published 2009.

General Information/Press Room. Published 2014. American Thyroid Association. https://www.thyroid.org/media-main/press-room/

Ojetti V; Nucera G;Migneco A; Gabrielli M; Lauritano C; Danese S; Zocco MA; Nista EC;Cammarota G;De Lorenzo A;Gasbarrini G;Gasbarrini A; High prevalence of celiac disease in patients with lactose intolerance. Digestion. https://pubmed.ncbi.nlm.nih.gov/15775678/. Published 2005.

Shahid MA. Physiology, Thyroid Hormone. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK500006/. Published May 18, 2020.

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The Importance of Hormones

Happy woman showing the importance of hormones.

Balanced hormones play a crucial role in the health of your entire body and mind. Hormonal imbalances are becoming more and more common, and they can cause many different symptoms depending on which hormones are high or low. People often don’t understand the importance of hormones, and how much they can affect quality of life. Let’s take a look at a few hormones that are commonly out of balance.

Testosterone

Testosterone is a hormone typically associated with men’s health. However, women need it too, but at lower levels than men. Testosterone plays a role in the production of sperm, red blood cells and muscle mass. It also plays a role in fat distribution, and helps regulate bone mass and sex drive. Testosterone is still being studied and researchers continue to learn more about how important this hormone is. Testosterone production often declines with age, and production may also decrease due to environmental toxins or certain health conditions.

Many men suffer from low testosterone, and symptoms may vary from person to person. Possible symptoms of low testosterone can include: fatigue, erectile dysfunction, hair loss, depression, poor memory, increased body fat, and decreased muscle mass, bone mass, and sex drive. Testosterone production often declines with age, and production may also decrease due to environmental toxins or certain health conditions. Some other things that can contribute to low testosterone include excess body fat (especially abdominal fat), high estrogen levels, and exposure to endocrine disruptors. Endocrine disruptors are substances that interfere with hormones and can be found in plastic, fragranced products like soap and perfume, and many other things.

Estrogen

Estrogen is a hormone found in both men and women, but is found in much higher amounts in women. It is plays a role in a healthy sex drive and healthy female development during puberty. Estrogen is also involved in reducing bone loss, increasing skin quality, and even helps regulate cholesterol production. This hormone has many different functions which is why it is so important to have healthy estrogen levels. However, a condition often known as estrogen dominance is on the rise. As discussed above, we are exposed to endocrine disruptors every day, and many of these chemicals mimic estrogen in the body. This can lead to unnaturally high levels of estrogen, which can increase your risk of certain cancers.

Symptoms of an estrogen imbalance in women can include headaches, decreased sex drive, mood swings, breast tenderness, bloating, sleeping issues, anxiety, weight gain, etc. Men who may be suffering from an estrogen dominance may experience symptoms like mood swings, erectile dysfunction, infertility, and increased breast tissue growth.

Even when estrogen levels are balanced, they don’t always metabolize into the healthy forms. Estrogen is metabolized into many different forms. Some of these estrogen metabolites have more carcinogenic potential than others, this is why we have many of our patients take DIM 150. DIM is derived from cruciferous vegetables and helps the body metabolize estrogen into weaker, safer forms. While DIM is still being studied extensively, it has already shown potential in possibly reducing breast and prostate cancer risk.

Progesterone

Progesterone is another chemical that is mostly associated with women, but men also produce small amounts of it. In men, progesterone is necessary for testosterone production, and low progesterone levels can contribute to hair loss. In women, progesterone plays an important role in many different functions and processes. While its main function is to ensure the uterus is prepared for a healthy pregnancy, it also works with estrogen to help promote healthy bone density. Symptoms of low progesterone in women can include irregular menstrual cycles, depression, anxiety, headaches, and possibly infertility and pregnancy difficulties.

Supplements

There are some supplements that may help with maintaining healthy hormone levels. These include:

  • Testo Essentials – Testo Essentials is a combination of natural herbal ingredients designed to help support healthy sexual activity and overall vitality in men.*
  • DIM 150 – Diindolylmethane (DIM) is a metabolite of indole-3-carbinol, a nutrient found in cruciferous vegetables. Studies have shown that DIM promotes healthy estrogen metabolism in both men and women by positively shifting the metabolism of estrogen toward protective 2-hydroxyestrogen metabolites instead of the 16-hydroxyestrone.
  • Progest-Avail – Progest-Avail™ is formulated to be used by women of reproductive age as well as by menopausal and postmenopausal women in order to ease any potential unpleasant effects of hormone imbalances and the normal hormonal fluctuations that occur with aging.
  • Evening Primrose Oil – Evening primrose supports cartilage and joint function, neuroendocrine and cognitive health, skin and connective tissue health, and helps maintain nerve function, and cardiovascular health.

Taking certain supplements may help provide the nutrients your body may be lacking, and they may help ensure detoxification pathways are open. Eating a diet high in organic fruits and vegetables may also be helpful in maintaining healthy levels of hormones. Choosing organic foods is important due to the hormonal disruption some pesticides can cause. Healthy hormones are vital to your health, so choose organic foods, naturally fragranced soaps and other products, and reduce plastic usage.

You can listen to our The Delicate Dance of Balancing Hormones podast episode where we discuss the importance of hormones here. You can also listen to it on our YouTube channel here.

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Adrenal Insufficiency

Tired woman; possible adrenal insufficiency.

Poor adrenal function is something we discuss frequently because it can have a big impact on overall health and well-being, and it is also one of the most common undiagnosed medical issues. Poor adrenal function can be hard to diagnose because it shares symptoms with many other medical conditions, but it is important to know the symptoms. Let’s look at what the adrenal glands and cortisol do, some causes of low cortisol, and what we can do about it.

Adrenal Glands and Cortisol

The adrenal glands are two small glands located on top of each kidney, and they are responsible for producing several different hormones including cortisol and adrenaline. Cortisol is often called the stress hormone because it is released when we experience stress due to physical exertion, traumatic events, or even something as simple as running late. Cortisol also plays an important role in regulating metabolism and blood sugar, reducing inflammation and forming memories, but as with other hormones, it needs to be balanced. Many people have too little or too much cortisol, and both come with negative impacts.

Adrenal insuffiency, or poorly functioning adrenal glands, usually leads to low cortisol. Low cortisol can cause low blood sugar, loss of appetite, weight loss, fatigue, low blood pressure, nausea, abdominal pain, trouble sleeping, depression, anxiety, etc. Low cortisol can affect a person’s well-being and energy levels, making it difficult to exercise, be productive at work, and can make it difficult to perform small tasks like getting out of bed or going to the store.

Causes

The causes of adrenal insufficiency can be hard to pinpoint. Arguably the most common cause is chronic stress which can put a strain on the adrenal glands, eventually causing them to produce less hormones than they are supposed to. It may also be caused by an autoimmune disorder that affects the adrenal glands. If the autoimmune reaction targets the adrenals, it can damage them and prevent them from functioning correctly. Lack of sleep and a poor diet may also contribute to impaired adrenal function because it contributes to stress, and poor sleep and nutrition can make it difficult for your body to repair any damage that may occur.

What to Do?

There are some things you can do to help ensure your adrenals have the right nutrients to help them function correctly. This includes getting at least eight hours of sleep per night, drinking plenty of filtered water each day, eating a diet high in organic fruits and vegetables, avoiding processed food and excessive amounts of sugar, and supplementing with herbs and vitamins that help regulate adrenal function. Some supplements we recommend are:

  • Adrenal Response Complete Care – Excellent formula containing adaptogenic herbs like ashwagandha that may help balance cortisol levels.
  • Pantothenic Acid Complex – This formula contains Cordyceps, Rhodiola Extract, Eleuthero Extract, and Pantothenic Acid to help support adrenal function.

Having adrenal insufficiency can make the smallest tasks difficult to complete, but giving your adrenals the sleep and nutrients it needs can go a long way!

If you are experiencing serious symptoms, or have a sudden change in symptoms, you should see a doctor right away to rule out more serious conditions.

You can listen to our Common Signs of Adrenal Insufficiency podcast here. You can also listen to it on our YouTube channel here.